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Encequidar mesylate

Name: Encequidar mesylate
Brand: TargetMol
SKU: T11578L
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11578LCas No. 849675-87-2

Alias HM30181A mesylate, HM30181 mesylate

Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.

Encequidar mesylate

🥰Excellent

Purity: 99.84%

Catalog No. T11578LAlias HM30181A mesylate, HM30181 mesylateCas No. 849675-87-2

Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$157	In Stock	In Stock
50 mg	$263	In Stock	In Stock
100 mg	$413	In Stock	In Stock
500 mg	$939	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
In vitro	Administration of Encequidar at concentrations of 0.1 or 1 nM resulted in a reduction of cell survival by 20% and 42% upon exposure to 100 nM and 1000 nM of NSC 125973, respectively [2].
In vivo	When administered simultaneously, Encequidar demonstrates increased plasma concentrations with the microcapsule formulation compared to the powder, showing notable differences from 1 to 2 hours. The microcapsule formulation achieves a 1.7-fold quicker Tmax and a 1.6-fold greater AUC value than the powder (2.5±0.6 vs. 4.3±0.9 hours; 107.7±20.1 vs. 64.3±18.0 h ng/mL), indicating faster and more efficient absorption. This enhanced absorption of Encequidar in microcapsule format is likely attributed to its improved aqueous solubility and dissolution rates, facilitated by the conversion from crystalline to amorphous form and the reduction in particle size [1].
Synonyms	HM30181A mesylate, HM30181 mesylate

Chemical Properties

Molecular Weight	784.83
Formula	C₃₉H₄₀N₆O₁₀S
Cas No.	849675-87-2
Smiles	CS(O)(=O)=O.COc1cc2CCN(CCc3ccc(cc3)-n3nnc(n3)-c3cc(OC)c(OC)cc3NC(=O)c3cc(=O)c4ccccc4o3)Cc2cc1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (70.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2742 mL	6.3708 mL	12.7416 mL	63.7081 mL
5 mM	0.2548 mL	1.2742 mL	2.5483 mL	12.7416 mL
10 mM	0.1274 mL	0.6371 mL	1.2742 mL	6.3708 mL
20 mM	0.0637 mL	0.3185 mL	0.6371 mL	3.1854 mL
50 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2742 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc